Oral verrucous carcinoma ovc is a rare but well differentiated form of oral squamous cell carcinoma mainly seen in sixth or seventh decade of life with male predominance. Adenosquamous carcinoma in buccal mucosaa case report. Sep 15, 2010 most treatment failure of buccal mucosal cancer post surgery is locoregional recurrence. Pathways involved in the spread of buccal carcinoma on. Oral cancer is a type of head and neck cancer and is any cancerous tissue growth located in the oral cavity1. Betel quid chewing is the main risk factor for buccal cancer in taiwan. Even though patients perceive carcinomatous lesions in the buccal mucosa early. Oral cancers rarely metastasize to the small intestines. Buccal squamous cell carcinoma is almost always preceded by premalignant conditions that include leukoplakia, erythroplakia, oral lichen planus, and submucous fibrosis of the oral cavity. Buccal mucosa cancer is common in india, t 4 tumours being the most common 66%. We performed an autopsy and confirmed metastatic lesions in the heart, lung, and liver that originated from the buccal mucosa carcinoma. Smokeless tobacco is found to be the most etiological factor in development.
We analyze our treatment results of this cancer and compare these results with those in the literature. The overall features were in favour of low grade mucoepidermoid carcinoma of minor salivary gland. Primary buccal sccas and their involvement could be evaluated on. Secondary cancers are severe complications in patients who have had allogeneic bone marrow transplantation for childhood leukemia. Ml asha 1, kanchan vini 2, ingita chatterjee 3, preeti patil 4. I am glad to write this foreword for consensus document for management of buccal mucosa cancer. The treatment algorithm for carcinoma of the buccal mucosa is similar to that for other sites in the oral cavity, with surgery indicated for earlystage lesions and combined therapy with surgery and port indicated for. Ildstad, st, bigelow, me, remensnyder, jp clinical behavior and results of current therapeutic modalities for squamous cell carcinoma of the buccal mucosa. Oral squamous cell carcinoma is a leading cause of mortality due to late diagnosis in india and most other developing countries.
Squamous cell carcinoma scc of the buccal mucosa in north america is thought to be different from that in the indian subcontinent. Buccal carcinoma was also common and accounted for approximately 30% of oral cavity cancers in china. Exposure of the cancer can be difficult via a transoral approach, which makes it difficult to obtain clear radial margins in an en bloc fashion. Patients with these types of swellings must be considered cautiously and a multidisciplinary approach can lead to successful treatment. Metastasis of carcinoma of buccal mucosa to small intestine. Surgical treatment outcomes of localized squamous carcinoma. A site specific clinical audit v singhania, bv jayade, v anehosur, k gopalkrishnan, n kumar department of oral and maxillofacial surgery, craniofacial unit, sdm college of dental sciences and hospital, dharwad, karnataka, india. Of 90 cases of squamous cell cancer of the buccal mucosa, the majority occurred in the posterior compartment of the cheek. Sixtyone percent 39 were t3 lesions, and 59% 38 had regional metastases. Tooth and advanced oral submucous fibrosis obscuring buccal. Catholic university of louvain, st luc university hospital. Most of those described as occurring in the oral cavity usually involve the gingiva and are not true bccs but peripheral ameloblastomas. Of 85 cases of squamous cell carcinoma of the buccal mucosa, 61 were treated primarily and 24 secondarily.
Squamous cell carcinoma scc of the buccal mucosa is rare and accounts for approximately 10% of all oral cancers1,2. Carcinoma of the buccal mucosa is the commonest cancer of the oral cavity in india, 1 in contrast to the west where carcinomas of the oral tongue or floor of mouth are more common. From the initial impression, the series of differential diagnosis consisted of 1 apical tooth infectioncausing reactive granuloma formed over the adjacent gingiva 2 squamous cell carcinoma of buccal mucosa and, 3 benign hyperplasia of the gingiva. Identification and profiling of micrornas expressed in oral. The present report is a case of adenosquamous carcinoma in a 75 years old man with a fast enlarging ulcerated lesion on right buccal mucosa. Jan 23, 2017 after thorough search of literature, we couldnt find a case report on buccal mucosa presenting with chest wall metastasis which makes this case extremely rare.
Most of these tumors are located on the parotid gland with very few cases reported in the minor salivary glands of the buccal mucosa. True basal cell carcinoma bcc involving the oral mucous membranes is extraordinarily rare. Chest wall metastasis in squamous cell carcinoma of buccal. Squamous cell carcinoma scc of the buccal mucosa is a rare, but especially aggressive, form of oral cavity cancer, associated with a high rate of locoregional recurrence and poor survival. Verrucous carcinoma of the buccal mucosa with extension to the cheek. On physical examination a warty papilliform lesion was seen on the left buccal mucosa with extension to 2 cm of the upper and lower lip on the left side including the left oral commissure and the skin of the left cheek beyond the. This retrospective study was performed to show the incidence of bone metastasis from carcinoma of the buccal mucosa. Health, general antimitotic agents analysis health aspects antineoplastic agents cancer care and treatment cancer treatment excision surgery methods medical research medicine, experimental radiation radiation physics. Furthermore, the thin distance between the buccal mucosa and the buccal space permits early invasion to deep structures or to anterior cheek skin.
Buccal mucosa cancer buccal mucosa cancers are often neglected or misdiagnosed as an infection or consequence of trauma, and thus, rarely present as t1 lesions. Squamous cell carcinoma of the buccal mucosa is common and roughly 2. Radiotherapy of carcinoma of the buccal mucosa wiley online. Bone metastasis in advanced cases of carcinoma buccal mucosa is rarely reported in the world literature. Adenoid cystic carcinoma acc is a malignant neoplasm that accounts for 1. Twentyseven patients received firsttime surgical therapy for buccal carcinoma. Incidence of bone metastasis in carcinoma buccal mucosa. The goal was to analyze the outcome of surgical therapy for buccal. Tissuebased in vitro and ex vivo models for buccal permeability studies. Although certainly not the only cause, buccal squamous cell carcinoma is associated with chewing betel nuts, which explains its high incidence in countries such as china, india 1 and taiwan, where this is common practice.
It is worth noting that swellings in the buccal mucosa and labial mucosal resembling a mucocele could turn out to be mec, as was the case in this report. An aggressive cancer requiring multimodality treatment chunshu lin, md,1 yeemin jen, md, phd,1 mingfang cheng, md,2 yaohshiang lin, md,3. Buccal carcinoma is an oral cavity cancer, and its incidence significantly differed between regions. Although these high risk sites are recognized, statistically, leukoplakia is more common on the buccal mucosa, alveolar mucosa, and the lower labial mucosa. The presence of the etv6ntrk3 fusion gene is essential in diagnosing secretory carcinoma. Vigneswaran n, muller s, lense e, stacey b, hewanlowe k, weathers dr. The peculiarity of the lesion and the approach we made is the key factor in the presentation. Threeyear diseasefreesurvival of 75 to 85 percent for stage i and 65 percent for stage ii cancers have been reported. Between august 2000 and june 2008, a total of 110 patients with buccal mucosa carcinoma 25 with stage i, 31 with stage ii, 11 with stage iii, and 43 with stage iv.
This is an open access article distributed under the terms of the creative commons attributionnoncommercialsharealike 3. The buccal mucosa is the lining of the cheeks and the back of the lips, inside the mouth where they touch the teeth. In pn0pnx subjects, neck control was predicted by perineural invasion and the absence of neck dissection in tongue cancer, and by poor differentiation in buccal cancer. Studies about buccal mucosa cancer squamous cell carcinoma of the buccal mucosa is a rare, but especially aggressive, form of oral cavity cancer, associated with a high rate of locoregional recurrence and poor survival. Between august 2000 and june 2008, a total of 110 patients with buccal mucosa carcinoma 25 with stage i, 31 with stage ii, 11 with stage iii, and 43 with stage iv classified according to the american. Most treatment failure of buccal mucosal cancer post surgery is locoregional recurrence.
This extends to the line of attachment of the mucosa of the upper and lower alveolar ridge superiorly and. Ahmed dental college and hospital, west bengal university of health sciences, kolkata. Sixtyeight percent were t 2 or t 3 lesions, 48% had regional metastases, 19% had systemic spread, and 40% showed local recurrence. This is a retrospective study of localized squamous carcinoma of the buccal mucosa treated with peroral wide excision at a major tertiary. Adenoid cystic carcinoma is a malignant neoplasm most commonly originating in salivary glands of head and neck region. Epidemiology after carcinoma of the lip, oral tongue, floor of the mouth, and lower gum, carcinoma of the buccal mucosa is the fifth most common carcinoma of the oral cavity.
In conclusion, chest wall metastasis from squamous cell carcinoma of buccal mucosa is a rare occurrence with no reported case in published literature. This clinical photo depicts squamous cell carcinoma of the buccal mucosa. Buccal carcinomas with involvement of the adjacent oral cavity subsites were included only if it was clear from clinical records that the tumor arose from the buccal mucosa. This study compared the treatment outcomes and prognostic factors in 64 patients with scc of the buccal mucosa treated at cancer care manitoba ccmb, canada, and 64 similar patients treated at the tata memorial hospital tmh, india. The purpose of the study was to analyze the outcomes after surgical therapy peroral wide excision for early squamous carcinoma of the buccal mucosa. Squamous cell carcinoma of the buccal mucosa in a young.
In a previously operated case of squamous cell carcinoma of buccal mucosa without any known preoperative distant metastases, we report a case of solitary ileal perforation 3 months after the surgery. This extends to the line of attachment of the mucosa of the upper and lower alveolar ridge superiorly and inferiorly. Squamous cell carcinoma is the most common pathology and more prevalent in those who use tobacco and alcohol. The exact etiology of the condition is unknown, though it is associated with human papillomavirus infection, traumatic scars, chronic infection, tobacco, and chemical carcinogens. Gopal chandra halder 1, jay gopal ray 1, santanu patsa 1. Staging of untreated squamous cell carcinoma of buccal mucosa.
This document is the result of the hard work of various experts across the country working in the area of oncology. Pdf verrucous carcinoma of the buccal mucosa a case. Incidence of bone metastasis in squamous cell carcinoma of. This website is a service of the national cancer institutes surveillance, epidemiology, and end results program and one of several resources for cancer registrars seerrsa home. An aggressive cancer requiring multimodality treatment.
Effect of betel chewing on the oral mucosa br j cancer 23, 3943 1969. Pdf squamous cell carcinoma of the buccal mucosa bmscc is an uncommon, but aggressive, form of oral cavity. Original article, clinical report by ear, nose and throat journal. Oral submucous fibrosis buccal squamous cell carcinoma quantitative proteomic analysis annexin a4 filamina.
Carcinoma buccal mucosa oral mucosa carcinoma causes. Secretory carcinoma of minor salivary gland in buccal mucosa. The high prevalence of chewing oral tobacco products is presumed to be the major cause for the higher incidence. Until 2004, only 59 cases of adenosquamous carcinoma have been documented in english literatures in the head and neck region since the first one being reported in 1968. Nd bloom, rh spirocarcinoma of the cheek mucosa, a retrospective analysis. The icmr had constituted subcommittee to prepare this document for management of various cancer sites. We compared normal oral mucosa nbm and paired biopsies of bscc and osf by. We tried to figure out how close the surgical margin being unsafe and needed further adjuvant treatment. Secretory carcinoma sc of the salivary gland was recently added to the fourth edition of the world health organization classification of head and neck tumors. Squamous cell carcinoma of the buccal mucosa com prises approximately 10% of all oral cancers in the. View enhanced pdf access article on wiley online library html view download pdf for offline viewing. Posttreatment surveillance, risk for recurrence of barretts esophagus, and adenocarcinoma after treatment.
Primary buccal carcinoma was defined as a malignant neoplastic process originating from the buccal mucosa. Quantitative proteomic analysis for novel biomarkers of buccal. Aug 09, 2018 carcinoma of the buccal mucosa is relatively uncommon in north america, compared with other oral cavity cancers such as carcinomas of the tongue or floor of the mouth. A case of basal cell carcinoma of the buccal mucosa with black pigmentation. Head and neck cancer is a leading health problem in india due to an increased incidence of tobacco use and poor oral hygiene. Identification and profiling of micrornas expressed in oral buccal mucosa squamous cell carcinoma of chinese hamster. The use of tobacco and alcohol makes cancer in this area far more likely. Here we present a case report of a 50 year old male who was diagnosed with adenoid cystic carcinoma of the right buccal mucosa. Pdf a case of basal cell carcinoma of the buccal mucosa. Diaz em jr, holsinger fc, zuniga er, roberts db, sorensen dm. Cureus squamous cell carcinoma of left buccal alveolar ridge. Records of 100 consecutive cases of carcinoma of the buccal mucosa treated in our. Adenosquamous carcinoma in buccal mucosa a case report. She was referred to our center because of a mass in left buccal mucosa.
We describe here a case of squamous cell carcinoma scc of the buccal mucosa in a young adult patient who had had allogeneic bone marrow transplantation for childhood acute leukemia. Some salivary tumors, including acinic cell carcinoma, have been reclassified as sc. Carcinoma buccal mucosa anatomy to management slideshare. Squamous cell carcinoma of the buccal mucosa involving the. It is the most common carcinoma of the oral cavity in india, malaysia, and taiwan. The disease is treated with surgery, chemotherapy or both. Basal cell carcinoma of the buccal mucosa researchgate. As the isolated basal cell carcinoma of the oral cavity has also been reported 7, a careful histopathological evaluation is.
The significance of cutaneous horns is that they occur in association with, or as a response to, a wide variety of underlying benign, premalignant, and malignant cutaneous diseases. Surgery for cancer of the buccal mucosa pradhan 1989. Bone metastasis in advanced cases of carcinoma buccal mucosa is rarely reported in. Chest wall metastasis in squamous cell carcinoma of buccal mucosa. In cases of buccal tumors that included other oral subsites, the case was only included if it was clear from the clinical record that the tumor originally arose from buccal mucosa. In an investigation of the development sites of oral scc in koreans, the buccal mucosa was reported to be the fourth most common site following the mandible, tongue, and maxilla3. Pdf metastasis of adenoid cystic carcinoma of buccal.
Merkel cell carcinoma of the buccal mucosa and lower lip. Marginal mandibulectomy is commonly performed for cancer of the floor of the mouth or buccal mucosa cancer that involves the gingiva. Clinicopathologic evaluation of prognostic factors for. Thirtynine percent of the patients were treated by surgery alone, and 58% were treated by irradiation initially. The edge of the ileal perforation was positive for squamous cell carcinoma on histopathology. Anatomy the buccal mucosa includes the mucosal surfaces of the cheek and lips from the line of contact of the opposing lips to the pterygomandibular raphe posteriorly.
Nearly half of the patients were more than 70 years of age. Squamous cell carcinoma of left buccal alveolar ridge. Tumour thickness and relationship to locoregional failurein cancer of. In this report, we describe a case of sc in a 52yearold woman. The buccal mucosa includes the mucosal surfaces of the cheek and lips from the line of contact of the opposing lips to the pterygomandibular raphe posteriorly. A case of secretory carcinoma that occurred in the buccal. The patient did not have a family history of tumor or carcinoma. A few patients carcinomas were diagnosed after biopsy of a leukoplakia on routine examination, and several had more advanced signs and symptoms such as trismus, ulcerations of cheek skin. The study took place in a major tertiarycare hospital.
Addressing squamous cell carcinoma of the buccal mucosa. The goal was to analyze the outcome of surgical therapy for buccal carcinoma. A true bcc, which arose on the buccal mucosa of a 69year old man, is reported. Cardiac metastasis of squamous cell carcinoma of the buccal mucosa. We intend to define the pattern and incidence of failure of buccal cancer and provide information for the design of a better multimodality treatment. A case of giant cutaneous horn of left oral commissure along with carcinoma left buccal mucosa is reported here as an extremely rare oralperioral pathology. Carcinoma buccal mucosa underlying a giant cutaneous horn. Immunohistologically, it is thought to be positive for s100 protein, vimentin, and mammaglobin and negative for dog1. Verrucous carcinoma of the buccal mucosa with extension to. Most of the patients present in stage iii and iv and the survival in these cases is not very good. Leukoplakia of the floor of the mouth and tongue accounts for over 90% of leukoplakias showing dysplasia or carcinoma on biopsy.
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